Evidensniveauer

For at give et overblik over evidensniveauet for de enkelte anbefalinger blev den foreliggende evidens adapteret fra de inkluderede guidelines og sammenfattet i tre evidensniveauer A, B og C, se tabel 2.

I tilfælde af uoverensstemmelse mellem evidensniveauerne i de canadiske og engelske retningslinjer, valgte arbejdsgruppen at overføre evidensniveauet fra de canadiske retningslinjer grundet deres højere kvalitetsscore.

I tilfælde hvor der var usikkerhed om evidensniveauet i de canadiske og engelske retningslinjer, valgte arbejdsgruppen at tildele evidensniveau C.

Tabel 2. Oversigt over evidensniveauer anvendt i disse retningslinjer

 

Arbejdsgruppens retningslinjer

 

Canadiske retningslinjer

 

Engelske retningslinjer

[A] Stærk evidens

A

At least one meta-analysis, systematic review or RCT rated as 1++, and directly applicable to the target population; or a systematic review of RCTs or a body of evidence consisting principally of studies rated as 1+, directly applicable to the target population and demonstrating overall consistency of results

A

High-quality diagnostic studies in which a new test is independently and blindly compared with a reference standard in an appropriate spectrum of patients

Systematic review and meta-analyses of such high-quality studies

[B] Moderat evidens

B

A body of evidence including studies rated as 2++, directly applicable to the target population and demonstrating overall consistency of results; or extrapolated evidence from studies rated as 1++ or 1+

B

- Studies with a blind and independent comparison of the new test with the reference standard in a set of non-consecutive patients or confined to a narrow spectrum of patients

- Studies in which the reference standard was not applied to all patients

- Systematic reviews of such studies

[C] Svag evidens

C

A body of evidence including studies rated as 2+, directly applicable to the target population and demonstrating overall consistency of results; or extrapolated evidence from studies rated as 2++**

C

Studies in which the reference standard was not objective

- Studies in which the comparison of the new test with the reference standard was not blind or independent

- Studies in which positive and negative test results were verified using different reference standards

- Expert opinion

D

Evidence level 3 or 4; or extrapolated evidence from studies rated as 2+; or evidences from trials classified as (minus) regardless of the level

Good practice point (GPP)

Recommended best practice based on the clinical experience of the guideline development group, without research evidence